High throughput screening

Novel Topical Microbicides Through Combinatorial Strategies

Pharmacy / Biomedicine / Biomedical Engineering / Medical Law / Humans / Escherichia coli / High throughput screening / Pharmaceutical / Antibacterial activity / Very high throughput / Microbicide / Microbial Sensitivity Tests / Surface Active Agents / Lethal Dose / Combinatorial / Escherichia coli / High throughput screening / Pharmaceutical / Antibacterial activity / Very high throughput / Microbicide / Microbial Sensitivity Tests / Surface Active Agents / Lethal Dose / Combinatorial

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Antifungal Tradecraft by Cholesterol Oxidase

Organic Chemistry / Catalysis / Statistical Analysis / Protein Engineering / High throughput screening / Cholesterol / Pseudomonas / Enzyme / Substrate Specificity / Antifungal Agents / Chemical Properties / Chemistry Biology / Ergosterol / Function Space / Enzymatic Activity / Biochemistry and cell biology / Cholesterol / Pseudomonas / Enzyme / Substrate Specificity / Antifungal Agents / Chemical Properties / Chemistry Biology / Ergosterol / Function Space / Enzymatic Activity / Biochemistry and cell biology

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A human immunodeficiency virus type 1 protease biosensor assay using bioluminescence resonance energy transfer

Microbiology / Molecular Biology / Medical Microbiology / Virology / Molecular virology / Quantitative Methods / Cell Biology / Fluorescence Resonance Energy Transfer / HIV / Cell line / Humans / Negative Affect / HIV protease / Virus / High throughput screening / Method / Biosensor / Bioluminescence / Green Fluorescent Protein / Journal of Virological Methods / Human immunodeficiency virus / Hiv Aids / Western blot / Microbial Sensitivity Tests / Energy Transfer / Protein Binding / Biosensing Techniques / Quantitative Methods / Cell Biology / Fluorescence Resonance Energy Transfer / HIV / Cell line / Humans / Negative Affect / HIV protease / Virus / High throughput screening / Method / Biosensor / Bioluminescence / Green Fluorescent Protein / Journal of Virological Methods / Human immunodeficiency virus / Hiv Aids / Western blot / Microbial Sensitivity Tests / Energy Transfer / Protein Binding / Biosensing Techniques

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Experimental and computational approaches to electrical conductor loading characteristics

Pharmacology / Thermodynamics / Physical Chemistry / Polymorphism / Protein Folding / Drug Discovery / Drug delivery / Rule of Law / Adsorption / Protein Design / Computers / Permeability / High throughput screening / Advanced Drug Delivery Research / Gene Network / Solubility / Free Energy / Protein Function / Biological Network / Biological systems / Molecular weight / Rule Based / Pharmaceutical preparations / Drug Discovery / Drug delivery / Rule of Law / Adsorption / Protein Design / Computers / Permeability / High throughput screening / Advanced Drug Delivery Research / Gene Network / Solubility / Free Energy / Protein Function / Biological Network / Biological systems / Molecular weight / Rule Based / Pharmaceutical preparations

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Oxazolidinones as novel human CCR8 antagonists

Organic Chemistry / Chemokines and chemokine receptors / Humans / Computer Simulation / High throughput screening / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones

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Dietary polyphenols identified as intracellular protein kinase A inhibitors

Nutrition and Dietetics / Mass Spectrometry / Cell Signaling / Flavonoids / Signal Transduction / Cell line / Humans / Polyphenols / Green Tea / High throughput screening / Chronic Disease / Luminescence / High Performance Liquid Chromatography / High Pressure Liquid Chromatography / European / Phenols / Very high throughput / Transfection / Extraction Method / Protein Kinase / Dietary Protein / Intracellular Signaling / Cell line / Humans / Polyphenols / Green Tea / High throughput screening / Chronic Disease / Luminescence / High Performance Liquid Chromatography / High Pressure Liquid Chromatography / European / Phenols / Very high throughput / Transfection / Extraction Method / Protein Kinase / Dietary Protein / Intracellular Signaling

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Tetrahydro-4-quinolinamines identified as novel P2Y1 receptor antagonists

Organic Chemistry / Humans / Platelet aggregation / High throughput screening / Thrombosis / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure

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Tetrahydro-4-Quinolinamines Identified as Novel P2Y1 Receptor Antagonists

Organic Chemistry / Humans / Platelet aggregation / High throughput screening / Thrombosis / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure / Bioorganic and medicinal Chemistry / Structure activity Relationship / Molecular Structure

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Computer-based fluorescence quantification: a novel approach to study nucleolar biology

RNA / Kinetics / Fluorescence Microscopy / Cell Cycle / Image Analysis / Humans / High throughput screening / Stress response / Single Cell / HeLa cells / Very high throughput / Biological Process / Large Data Sets / Biochemistry and cell biology / Image Acquisition / Automatic data processing / Humans / High throughput screening / Stress response / Single Cell / HeLa cells / Very high throughput / Biological Process / Large Data Sets / Biochemistry and cell biology / Image Acquisition / Automatic data processing

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A human immunodeficiency virus type 1 protease biosensor assay using bioluminescence resonance energy transfer

Microbiology / Molecular Biology / Medical Microbiology / Virology / Molecular virology / Quantitative Methods / Cell Biology / Fluorescence Resonance Energy Transfer / HIV / Cell line / Humans / Negative Affect / HIV protease / Virus / High throughput screening / Method / Biosensor / Bioluminescence / Green Fluorescent Protein / Journal of Virological Methods / Human immunodeficiency virus / Hiv Aids / Western blot / Microbial Sensitivity Tests / Energy Transfer / Protein Binding / Biosensing Techniques / Quantitative Methods / Cell Biology / Fluorescence Resonance Energy Transfer / HIV / Cell line / Humans / Negative Affect / HIV protease / Virus / High throughput screening / Method / Biosensor / Bioluminescence / Green Fluorescent Protein / Journal of Virological Methods / Human immunodeficiency virus / Hiv Aids / Western blot / Microbial Sensitivity Tests / Energy Transfer / Protein Binding / Biosensing Techniques

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Nonnucleoside Inhibitor of Measles Virus RNA-Dependent RNA Polymerase Complex Activity

Microbiology / Medical Microbiology / Enzyme Inhibitors / Measles Virus / Dogs / Cercopithecus aethiops / Cell line / Cell fusion / High throughput screening / Animals / Drug Design / Case Management / Spectrum / Antimicrobial agents / Transfection / Structure activity Relationship / RNA Dependent RNA Polymerase / Chemical Synthesis / Vero cells / Antiviral Agents / Molecular Structure / Cercopithecus aethiops / Cell line / Cell fusion / High throughput screening / Animals / Drug Design / Case Management / Spectrum / Antimicrobial agents / Transfection / Structure activity Relationship / RNA Dependent RNA Polymerase / Chemical Synthesis / Vero cells / Antiviral Agents / Molecular Structure

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Oxazolidinones as novel human CCR8 antagonists

Organic Chemistry / Chemokines and chemokine receptors / Humans / Computer Simulation / High throughput screening / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones / Animals / Bioorganic and medicinal Chemistry / Structure activity Relationship / Oxazolidinones

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Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists

Organic Chemistry / Humans / G protein-coupled receptors / High throughput screening / Structure activity Relationship

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Gradient, Contact-Free Volume Transfers Minimize Compound Loss in Dose-Response Experiments

Fluorescence / Pharmaceutical Technology / High throughput screening / Free volume / Water soluble polymers / Biochemistry and cell biology / Fluorescein / Biochemistry and cell biology / Fluorescein

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Neurobehavioral mutants identified in an ENU-mutagenesis project

Genetics / Animal Behavior / Fear / Learning and Memory / Prepulse Inhibition / Mutagenesis / Mice / High throughput screening / Female / Animals / Male / Open Field / Genetic Map / Central Nervous System / Mental Disorders / Pedigree / Mental Disorder / Mouse Model / Large Scale / Nervous System Diseases / Mutagenesis / Mice / High throughput screening / Female / Animals / Male / Open Field / Genetic Map / Central Nervous System / Mental Disorders / Pedigree / Mental Disorder / Mouse Model / Large Scale / Nervous System Diseases

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6-Amino-4-(pyrimidin-4-yl)pyridones: Novel glycogen synthase kinase-3β inhibitors

Organic Chemistry / Pharmacokinetics / Macromolecular X-Ray Crystallography / In Vitro / Humans / High throughput screening / Central Nervous System / In Vivo / Rat / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure / High throughput screening / Central Nervous System / In Vivo / Rat / Bioorganic and medicinal Chemistry / Structure activity Relationship / Chemical Synthesis / Protein Kinase Inhibitors / Molecular Structure

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